Team uses AlphaFold AI to redesign gene-editing proteins to make them safer

A couple of decades after the discovery of systems that could selectively target DNA, we're starting to see the first therapies based on gene editing. One challenge these developments have faced is safety. While we can make them pretty specific to the gene we want edited, the human genome is very large, and even rare DNA sequences can appear a couple of times by chance. As a result, all the original gene-editing systems had known rates of what are called off-target effects, in which they simply